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C Gajate Selected Research

edelfosine

5/2012Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
5/2011Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.
7/2010Lipid raft-targeted therapy in multiple myeloma.
12/2001The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.
3/2000Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis.

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C Gajate Research Topics

Disease

7Neoplasms (Cancer)
05/2012 - 03/2000
2Multiple Myeloma
07/2010 - 09/2009
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
05/2013
1Infections
12/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2012
1Mitochondrial Diseases (Mitochondrial Disease)
05/2011
1Carcinoma (Carcinomatosis)
05/2011
1T-Cell Leukemia (Leukemia, T Cell)
09/2009

Drug/Important Bio-Agent (IBA)

7LipidsIBA
05/2013 - 03/2000
5edelfosineIBA
05/2012 - 03/2000
3Pharmaceutical PreparationsIBA
05/2012 - 03/2000
2Antineoplastic Agents (Antineoplastics)IBA
05/2012 - 05/2011
2Ether (Diethyl Ether)IBA
12/2001 - 03/2000
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2012
1Phosphotransferases (Kinase)IBA
05/2012
1Caspase 3 (Caspase-3)IBA
05/2012
1CaspasesIBA
05/2012
1LysophospholipidsIBA
05/2012
1Prokaryotic Initiation Factor-2IBA
05/2012
1CholesterolIBA
07/2010
1Death Domain ReceptorsIBA
09/2009
1LigandsIBA
09/2009
1Proteins (Proteins, Gene)FDA Link
09/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2009
1fas Receptor (CD95 Antigen)IBA
09/2009
1ResveratrolIBA
09/2009
1JNK Mitogen-Activated Protein KinasesIBA
09/2009
1Caspase 8 (Caspase-8)IBA
09/2009
1Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2008

Therapy/Procedure

3Therapeutics
05/2012 - 07/2010
2Oral Administration
05/2012 - 07/2010
2Drug Therapy (Chemotherapy)
05/2011 - 10/2003